Our interest
The Sun Lab is interested in deciphering the RNA processing pathways altered by the ALS-causative mutants to uncover the mechanisms of toxicity and molecular basis of cell type-selective vulnerability. Another major focus of the group is to identify small molecule and genetic inhibitors of neuron toxic factors using various high-throughput screening platforms. Finally, we are also highly interested in developing novel CRISPR technique-based therapeutic strategies. We seek to translate the mechanistic findings at molecular level to therapeutic target development to advance treatment options against neurodegenerative diseases.
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Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurological disease that affects nerve cells responsible for controlling voluntary muscles. As these nerve cells deteriorate, muscle weakness and loss of motor function occur, eventually leading to difficulties with speaking, swallowing, and breathing. The disease typically progresses quickly and can result in complete paralysis. Unfortunately, there is no cure for ALS, but treatments can help manage symptoms.
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RNA metabolism dysfunction in neurodegeneration
The nervous system has extremely complex RNA processing regulation. Dysfunction of RNA metabolism has emerged to play crucial roles in multiple neurological diseases. Mutations and pathologies of several RNA-binding proteins are found to be associated with neurodegeneration in both ALS and FTD.
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